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Evolution of MICs after successive exposures of bacteria to sublytic concentrations of the specified antimicrobial agent. (A and B) Evolution of MICs after 15 and 10 serial passages of P. aeruginosa and S. aureus, respectively. The relative MIC is the normalized ratio of the MIC obtained for a given subculture to the MIC (determined concomitantly) obtained for first-time exposure.
