TABLE 1.
Amino acid sequences of the dermaseptin S4 derivatives and their antibacterial activities against 66 multidrug-resistant clinical isolates
| Peptide | Amino acid sequencea | MIC (μg/ml)b
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
S. aureus (n = 23)
|
P. aeruginosa (n = 17)
|
E. coli (n = 26)
|
||||||||||
| 50% | 90% | Range | 50% | 90% | Range | 50% | 90% | Range | ||||
| K4K20-S4 | ALWKTLLKKVLKAAAKAALKAVLVGANA | 1 | 2 | 1-4 | 2 | 2 | 1-4 | 4 | 8 | 1-16 | ||
| K4-S4(1-16) | ALWKTLLKKVLKAAAKa | 2 | 4 | 0.5-8 | 4 | 4 | 1-8 | 2 | 4 | 1-8 | ||
| K4-S4(1-13) | ALWKTLLKKVLKAa | 4 | 8 | 1-16 | 8 | 8 | 2-16 | 4 | 8 | 2-16 | ||
a
a, amide.
b
50% and 90%, MICs (based on amino acid analysis) at which 50 and 90% of the tested clinical isolates were inhibited, respectively.