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. 2025 Dec 28;22(12):981–991. doi: 10.26599/1671-5411.2025.12.001

Table 3. Multivariable Cox regression analysis of SHR for clinical outcomes.

Outcome Model 1 Model 2 Model 3
HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value
Hazard ratio (HR) with 95% CI was estimated using Cox proportional hazards regression. Model 1: adjusted for age, sex, and body mass index. Model 2: adjusted for variables in Model 1 plus the smoking, DM, hypertension, prior myocardial infarction, and clinical presentation. Model 3: adjusted for variables in Model 2 plus the LVEF, multivessel disease, ≥ 2 stents, statin, LDL-C, stent implantation, and cardiac troponin I. DM: diabetes mellitus; LDL-C: low-density lipoprotein cholesterol; LVEF: left ventricular ejection fraction; MACE: major adverse cardiovascular event; SHR: stress hyperglycemia ratio.
Cardiac death
Q1 (< 0.93) 1.26 (0.80–1.99) 0.314 1.23 (0.78–1.94) 0.380 1.20 (0.76–1.90) 0.433
Q2 (0.93–1.11) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Q3 (1.11–1.34) 1.29 (0.82–2.02) 0.268 1.2 (0.77–1.89) 0.424 1.24 (0.79–1.95) 0.350
Q4 (≥ 1.34) 1.93 (1.27–2.93) 0.002 1.75 (1.15–2.68) 0.009 1.56 (1.02–2.39) 0.042
All-cause death
Q1 (< 0.93) 1.3 (0.89–1.91) 0.176 1.26 (0.86–1.85) 0.244 1.24 (0.84–1.83) 0.273
Q2 (0.93–1.11) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Q3 (1.11–1.34) 1.37 (0.94–1.99) 0.101 1.30 (0.89–1.89) 0.178 1.34 (0.92–1.96) 0.125
Q4 (≥ 1.34) 1.74 (1.22–2.50) 0.002 1.61 (1.12–2.32) 0.010 1.48 (1.03–2.13) 0.036
MACE
Q1 (< 0.93) 1.28 (0.99–1.66) 0.056 1.25 (0.96–1.62) 0.092 1.25 (0.96–1.62) 0.093
Q2 (0.93–1.11) 1.00 (Reference) 1.00 (Reference) 1.00 (Reference)
Q3 (1.11–1.34) 1.30 (1.01–1.68) 0.043 1.24 (0.95–1.60) 0.108 1.27 (0.98–1.64) 0.072
Q4 (≥ 1.34) 1.52 (1.19–1.95) 0.001 1.41 (1.09–1.82) 0.008 1.34 (1.04–1.73) 0.023