TABLE 1.
Comparative in vitro activities of BAL9141 against 244 gram-negative nonfermenters
| Organism (no. of strains) and drug | MIC (μg/ml)
|
Organism (no. of strains) and drug | MIC (μg/ml)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Range | 50% | 90% | Range | 50% | 90% | |||
| Achromobacter xylosoxidans subsp. denitrificans and A. xylosoxidans subsp. xylosoxidans (17) | ||||||||
| BAL9141 | 1-32 | 4 | 16 | |||||
| Cefepime | 2->64 | 32 | >64 | |||||
| Cefotetan | 32->64 | >64 | >64 | |||||
| Cefozopran | 8->64 | >64 | >64 | |||||
| Ceftazidime | 1-32 | 8 | 16 | |||||
| Ceftriaxone | 1->64 | 64 | >64 | |||||
| Amoxicillin-clavulanic acid | 8->64 | 32 | >64 | |||||
| Ticarcillin-clavulanic acid | 2-64 | 8 | 64 | |||||
| Imipenem | 0.25-4 | 2 | 4 | |||||
| Ciprofloxacin | 1-32 | 4 | 8 | |||||
| Acinetobacter baumannii (10) | ||||||||
| BAL9141 | 0.5->64 | 2 | 16 | |||||
| Cefepime | 1->64 | 8 | 32 | |||||
| Cefotetan | 32->64 | 64 | >64 | |||||
| Cefozopran | 1-64 | 8 | 32 | |||||
| Ceftazidime | 2->64 | 8 | 64 | |||||
| Ceftriaxone | 4->64 | 16 | 64 | |||||
| Amoxicillin-clavulanic acid | 32->64 | 64 | >64 | |||||
| Ticarcillin-clavulanic acid | 1->64 | 64 | >64 | |||||
| Imipenem | 0.25-4 | 0.5 | 0.5 | |||||
| Ciprofloxacin | ≤0.06->64 | 0.25 | 0.25 | |||||
| Acinetobacter iwoffii (10) | ||||||||
| BAL9141 | ≤0.06 | ≤0.06 | ≤0.06 | |||||
| Cefepime | ≤0.06-1 | ≤0.06 | 0.5 | |||||
| Cefotetan | 0.5-64 | 4 | 32 | |||||
| Cefozopran | ≤0.06-0.5 | ≤0.06 | ≤0.06 | |||||
| Ceftazidime | ≤0.06-8 | 0.5 | 4 | |||||
| Ceftriaxone | ≤0.06-4 | 1 | 2 | |||||
| Amoxicillin-clavulanic acid | ≤0.06-8 | 2 | 8 | |||||
| Ticarcillin-clavulanic acid | 0.25-8 | 2 | 4 | |||||
| Imipenem | ≤0.06-0.13 | ≤0.06 | 0.13 | |||||
| Ciprofloxacin | ≤0.06 | ≤0.06 | ≤0.06 | |||||
| Agrobacterium radiobacter (10) | ||||||||
| BAL9141 | ≤0.06-0.5 | 0.13 | 0.25 | |||||
| Cefepime | 1-8 | 2 | 8 | |||||
| Cefotetan | 0.25-8 | 4 | 8 | |||||
| Cefozopran | 1-16 | 4 | 8 | |||||
| Ceftazidime | 4-64 | 64 | 64 | |||||
| Ceftriaxone | 1-32 | 4 | 16 | |||||
| Amoxicillin-clavulanic acid | 0.25-16 | 16 | 16 | |||||
| Ticarcillin-clavulanic acid | 4-16 | 8 | 16 | |||||
| Imipenem | ≤0.06-1 | 0.25 | 0.25 | |||||
| Ciprofloxacin | ≤0.06-1 | ≤0.06 | 0.5 | |||||
| Alcaligenes faecalis (10) | ||||||||
| BAL9141 | 0.25-8 | 0.5 | 2 | |||||
| Cefepime | 0.25->64 | 8 | 8 | |||||
| Cefotetan | 0.5->64 | 2 | >64 | |||||
| Cefozopran | 0.5->64 | 8 | 16 | |||||
| Ceftazidime | 2-16 | 4 | 8 | |||||
| Ceftriaxone | 0.13->64 | 0.25 | >64 | |||||
| Amoxicillin-clavulanic acid | 8-64 | 16 | 64 | |||||
| Ticarcillin-clavulanic acid | 4-16 | 8 | 8 | |||||
| Imipenem | ≤0.06-4 | 0.5 | 4 | |||||
| Ciprofloxacin | ≤0.06-4 | 1 | 4 | |||||
| Bordetella bronchiseptica (10) | ||||||||
| BAL9141 | 0.06-8 | 2 | 4 | |||||
| Cefepime | 0.25-64 | 16 | 32 | |||||
| Cefotetan | 8->64 | >64 | >64 | |||||
| Cefozopran | 0.25->64 | 32 | 32 | |||||
| Ceftazidime | 1-32 | 16 | 32 | |||||
| Ceftriaxone | 0.5->64 | >64 | >64 | |||||
| Amoxicillin-clavulanic acid | 8-64 | 16 | 64 | |||||
| Ticarcillin-clavulanic acid | 4->64 | 16 | 32 | |||||
| Imipenem | 0.13-2 | 1 | 2 | |||||
| Ciprofloxacin | ≤0.06-2 | 1 | 2 | |||||
| Brevundimonas vesicularis (14) | ||||||||
| BAL9141 | 1->64 | 4 | >64 | |||||
| Cefepime | 0.25-32 | 8 | 32 | |||||
| Cefotetan | 8->64 | 32 | >64 | |||||
| Cefozopran | 1->64 | 8 | >64 | |||||
| Ceftazidime | 0.5->64 | 32 | >64 | |||||
| Ceftriaxone | 0.5->64 | 4 | >64 | |||||
| Amoxicillin-clavulanic acid | 4->64 | 8 | >64 | |||||
| Ticarcillin-clavulanic acid | 4->64 | 16 | >64 | |||||
| Imipenem | 0.25->64 | 0.5 | >64 | |||||
| Ciprofloxacin | 0.25-16 | 4 | 16 | |||||
| Burkholderia cepacia (14) | ||||||||
| BAL9141 | 0.5-64 | 8 | 64 | |||||
| Cefepime | ≤0.06-32 | 8 | 32 | |||||
| Cefotetan | 8->64 | 64 | >64 | |||||
| Cefozopran | 16->64 | 64 | >64 | |||||
| Ceftazidime | 2-32 | 16 | 16 | |||||
| Ceftriaxone | 4->64 | 16 | 64 | |||||
| Amoxicillin-clavulanic acid | >64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | >64 | >64 | >64 | |||||
| Imipenem | ≤0.06-16 | 8 | 8 | |||||
| Ciprofloxacin | 1-4 | 1 | 4 | |||||
| Chryseobacterium indologenes (14) | ||||||||
| BAL9141 | 0.25->64 | 16 | 64 | |||||
| Cefepime | ≤0.06-16 | 1 | 4 | |||||
| Cefotetan | 4->64 | >64 | >64 | |||||
| Cefozopran | 0.5->64 | 4 | >64 | |||||
| Ceftazidime | 4-32 | 8 | 32 | |||||
| Ceftriaxone | 8-64 | 64 | 64 | |||||
| Amoxicillin-clavulanic acid | 0.5->64 | 32 | >64 | |||||
| Ticarcillin-clavulanic acid | 2->64 | >64 | >64 | |||||
| Imipenem | ≤0.06->64 | 16 | >64 | |||||
| Ciprofloxacin | ≤0.06-2 | 0.5 | 0.5 | |||||
| Chryseobacterium meningo- septicum (10) | ||||||||
| BAL9141 | 8-64 | 32 | 64 | |||||
| Cefepime | 8-64 | 32 | 64 | |||||
| Cefotetan | 64->64 | >64 | >64 | |||||
| Cefozopran | 16->64 | 32 | 64 | |||||
| Ceftazidime | 64->64 | >64 | >64 | |||||
| Ceftriaxone | 32->64 | 64 | >64 | |||||
| Amoxicillin-clavulanic acid | 32->64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | >64 | >64 | >64 | |||||
| Imipenem | 32-64 | 32 | 64 | |||||
| Ciprofloxacin | 0.5-8 | 1 | 2 | |||||
| Comamonas acidovorans (10) | ||||||||
| BAL9141 | 1-32 | 4 | 16 | |||||
| Cefepime | 8->64 | 8 | 64 | |||||
| Cefotetan | 4 | 4 | 4 | |||||
| Cefozopran | 4->64 | 16 | 64 | |||||
| Ceftazidime | 0.5-4 | 1 | 2 | |||||
| Ceftriaxone | 1-64 | 8 | 32 | |||||
| Amoxicillin-clavulanic acid | 32->64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | 8->64 | 64 | >64 | |||||
| Imipenem | 0.25-4 | 1 | 2 | |||||
| Ciprofloxacin | ≤0.06-0.5 | 0.13 | 0.25 | |||||
| Moraxella spp. (10) (except M. catarrhalis) | ||||||||
| BAL9141 | ≤0.06-0.25 | ≤0.06 | 0.13 | |||||
| Cefepime | ≤0.06-2 | 0.5 | 1 | |||||
| Cefotetan | 0.13-8 | 1 | 8 | |||||
| Cefozopran | ≤0.06-1 | 0.5 | 1 | |||||
| Ceftazidime | ≤0.06-8 | 2 | 4 | |||||
| Ceftriaxone | ≤0.06-0.5 | ≤0.06 | 0.5 | |||||
| Amoxicillin-clavulanic acid | 0.13-1 | 0.25 | 0.5 | |||||
| Ticarcillin-clavulanic acid | ≤0.06-4 | 0.5 | 1 | |||||
| Imipenem | ≤0.06-0.25 | ≤0.06 | 0.13 | |||||
| Ciprofloxacin | ≤0.06-0.13 | ≤0.06 | 0.13 | |||||
| Ochrobactrum anthropi (10) | ||||||||
| BAL9141 | 0.5-2 | 1 | 2 | |||||
| Cefepime | 8-64 | 16 | 64 | |||||
| Cefotetan | 16->64 | 64 | >64 | |||||
| Cefozopran | 4->64 | 16 | >64 | |||||
| Ceftazidime | 64->64 | >64 | >64 | |||||
| Ceftriaxone | 2->64 | 8 | >64 | |||||
| Amoxicillin-clavulanic acid | 32->64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | 64->64 | >64 | >64 | |||||
| Imipenem | 1-2 | 1 | 2 | |||||
| Ciprofloxacin | ≤0.06-0.5 | 0.5 | 0.5 | |||||
| Oligella ureolytica (10) | ||||||||
| BAL9141 | 0.25->64 | 0.5 | >64 | |||||
| Cefepime | 0.25->64 | 4 | 16 | |||||
| Cefotetan | 0.13->64 | 64 | >64 | |||||
| Cefozopran | 1->64 | 2 | >64 | |||||
| Ceftazidime | 0.5->64 | 16 | >64 | |||||
| Ceftriaxone | ≤0.06-64 | 4 | 64 | |||||
| Amoxicillin-clavulanic acid | 0.25->64 | 8 | >64 | |||||
| Ticarcillin-clavulanic acid | 0.25->64 | 8 | >64 | |||||
| Imipenem | ≤0.06->64 | 0.5 | 64 | |||||
| Ciprofloxacin | ≤0.06-1 | 0.5 | 0.5 | |||||
| Pseudomonas aeruginosa (15) | ||||||||
| BAL9141 | 0.25-64 | 8 | 32 | |||||
| Cefepime | 1-16 | 4 | 16 | |||||
| Cefotetan | >64 | >64 | >64 | |||||
| Cefozopran | 0.5-16 | 2 | 16 | |||||
| Ceftazidime | 2-32 | 4 | 8 | |||||
| Ceftriaxone | 2->64 | >64 | >64 | |||||
| Amoxicillin-clavulanic acid | >64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | 8->64 | >64 | >64 | |||||
| Imipenem | 0.13-32 | 2 | 4 | |||||
| Ciprofloxacin | ≤0.06-2 | 0.13 | 2 | |||||
| Pseudomonas oryzihabitans (10) | ||||||||
| BAL9141 | ≤0.06-2 | 0.13 | 0.25 | |||||
| Cefepime | ≤0.06->64 | 0.13 | 8 | |||||
| Cefotetan | 0.5->64 | 2 | 32 | |||||
| Cefozopran | ≤0.06->64 | 0.13 | 0.5 | |||||
| Ceftazidime | 0.13->64 | 0.5 | 2 | |||||
| Ceftriaxone | 0.13->64 | 0.5 | 32 | |||||
| Amoxicillin-clavulanic acid | 2 | 2 | 2 | |||||
| Ticarcillin-clavulanic acid | 0.13->64 | 2 | 64 | |||||
| Imipenem | 0.13-2 | 0.13 | 0.25 | |||||
| Ciprofloxacin | ≤0.06-0.5 | ≤0.06 | 0.5 | |||||
| Pseudomonas stutzeri (12) | ||||||||
| BAL9141 | ≤0.06-16 | 1 | 16 | |||||
| Cefepime | ≤0.06->64 | 0.25 | >64 | |||||
| Cefotetan | ≤0.06->64 | 2 | 16 | |||||
| Cefozopran | ≤0.06->64 | 0.25 | >64 | |||||
| Ceftazidime | ≤0.06->64 | 1 | >64 | |||||
| Ceftriaxone | 0.13->64 | 2 | >64 | |||||
| Amoxicillin-clavulanic acid | 0.25-16 | 8 | 16 | |||||
| Ticarcillin-clavulanic acid | 0.25->64 | 8 | 64 | |||||
| Imipenem | 0.06-1 | 0.5 | 0.5 | |||||
| Ciprofloxacin | ≤0.06 | ≤0.06 | ≤0.06 | |||||
| Ralstonia pickettii (10) | ||||||||
| BAL9141 | 1-4 | 2 | 4 | |||||
| Cefepime | 1-4 | 2 | 4 | |||||
| Cefotetan | 8->64 | >64 | >64 | |||||
| Cefozopran | 0.25-4 | 2 | 4 | |||||
| Ceftazidime | 2-16 | 8 | 16 | |||||
| Ceftriaxone | ≤0.06-0.25 | 0.25 | 0.25 | |||||
| Amoxicillin-clavulanic acid | 1->64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | 2->64 | >64 | >64 | |||||
| Imipenem | ≤0.06-2 | 1 | 2 | |||||
| Ciprofloxacin | ≤0.06-0.25 | 0.13 | 0.25 | |||||
| Sphingomonas spp. (10) | ||||||||
| BAL9141 | 4-16 | 8 | 16 | |||||
| Cefepime | 2-16 | 2 | 8 | |||||
| Cefotetan | 64->64 | 64 | >64 | |||||
| Cefozopran | 0.5-16 | 4 | 16 | |||||
| Ceftazidime | 2->64 | 16 | >64 | |||||
| Ceftriaxone | 1-32 | 8 | 16 | |||||
| Amoxicillin-clavulanic acid | 8-32 | 16 | 32 | |||||
| Ticarcillin-clavulanic acid | 8->64 | >64 | >64 | |||||
| Imipenem | 0.5->64 | 32 | 64 | |||||
| Ciprofloxacin | ≤0.06-4 | 0.25 | 2 | |||||
| Stenotrophomonas maltophilia (15) | ||||||||
| BAL9141 | 0.5->64 | >64 | >64 | |||||
| Cefepime | 4->64 | >64 | >64 | |||||
| Cefotetan | 8->64 | 64 | >64 | |||||
| Cefozopran | 32->64 | >64 | >64 | |||||
| Ceftazidime | 4->64 | 64 | >64 | |||||
| Ceftriaxone | >64 | >64 | >64 | |||||
| Amoxicillin-clavulanic acid | 8->64 | >64 | >64 | |||||
| Ticarcillin-clavulanic acid | 16->64 | >64 | >64 | |||||
| Imipenem | 8->64 | >64 | >64 | |||||
| Ciprofloxacin | 0.5-8 | 4 | 8 | |||||
| Weeksella virosa (15) | ||||||||
| BAL9141 | ≤0.06-2 | ≤0.06 | 2 | |||||
| Cefepime | 0.5-16 | 4 | 16 | |||||
| Cefotetan | 0.5-8 | 2 | 4 | |||||
| Cefozopran | 0.25-32 | 0.25 | 8 | |||||
| Ceftazidime | 0.25-8 | 1 | 4 | |||||
| Ceftriaxone | 0.5-4 | 2 | 4 | |||||
| Amoxicillin-clavulanic acid | ≤0.06-0.5 | 0.13 | 0.5 | |||||
| Ticarcillin-clavulanic acid | 0.13-16 | 0.25 | 1 | |||||
| Imipenem | ≤0.06-0.13 | ≤0.06 | ≤0.06 | |||||
| Ciprofloxacin | <0.06-0.13 | <0.06 | 0.13 | |||||