TABLE 1.
Determination of the NOECs and EC50s of artemisinin, paraquat, and mipafox in brain stem neuronal cell cultures and artemisinin in cortical cell and astrocyte cultures after 24 h of treatmenta
| Criterion | Brain stem
|
Cortex, artemisinin
|
Astrocytes artemisinin
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Artemisinin
|
Paraquat
|
Mipafox
|
|||||||||
| NOEC | EC50 | NOEC | EC50 | NOEC | EC50 | NOEC | EC50 | NOEC | EC50 | ||
| Viability assay | 10 | >10 | 2 | 10 | 10 | >10 | 10 | >10 | 10 | >10 | |
| Tetramethylrhodamine | 0.1 | 5 | 5 | 9 | 10 | >10 | 1 | >10 | 0.1 | >10 | |
| ATP | <0.001 | 1 | 0.1 | 2 | 10 | >10 | 1 | >10 | 1 | >10 | |
a
Endpoints were cytotoxicity (viability assay), the inner mitochondrial membrane potential (tetramethylrhodamine), and intracellular glucose consumption. All values are in micrograms per milliliter.