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. 2025 Nov 23;15:45195. doi: 10.1038/s41598-025-29411-6

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — LBP induces ferroptosis in MCF-7 cells through the NRF2/HO-1 pathway. (A) NRF2 and HO-1 expression after LBP and ML385 (NRF2 inhibitor) treatment. (B) Quantitative analysis in (A), n = 3. (C) The expression of NRF2 and HO-1 after treatment with three SiRNAs (Si2226, Si1498, Si1439) targeting NRF2. (D) NRF2 and HO-1 expression after LBP and Si2226 (SiRNAs of NRF2) treatment. (E) Quantitative analysis in (D), n = 3. The Fe²⁺ levels in the cytoplasm (F) and mitochondria (G) after LBP and ML385 treatment, scale bar: 100 μm. The levels of MDA (H), GSH (I), T-AOC (J), and Fe²⁺ (K) after LBP and ML385 treatment. Data were expressed as Mean ± SD. *p < 0.05, **p < 0.01.