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. 2025 Nov 25;15:45339. doi: 10.1038/s41598-025-29527-9

Table 1.

Correlation between CPSF3 expression and clinicopathological characteristics in TCGA and ICGC HCC cohorts.

Variables TCGA (n = 344) ICGC (n = 232)
Low risk
group
High risk
group
P-value Low risk
group
High risk
group
P-value
Age (years) 0.209 0.424
 < 60 149 22 34 11
 ≥ 60 158 15 130 57
Sex 0.494 0.773
 Male 207 27 120 51
 Female 100 10 44 17
Prior- Malignancy - 0.604
 No - - 144 58
 Yes - - 20 10
Histologic grade 0.279 -
 G1/2 194 20 - -
 G3/4 113 17 - -

TNM

stage

0.012 0.001
 I/II 233 21 112 30
 III/IV 74 16 52 38
Survival status < 0.001 < 0.001
 Alive 216 14 144 45
 Dead 91 23 20 23

Bold values represent P-values less than 0.05.

Notes: TCGA: The Cancer Genome Atlas, HCC: hepatocellular carcinoma, AJCC: American Joint Committee on Cancer.