TABLE 2.
Effects of NRTIs on in vitro production of lactic acid
| Drug | Concn (μM) | Lactic acid production (mg/106 cells)a
|
|
|---|---|---|---|
| HepG2 cells | SkMCs | ||
| None | 1.61 ± 0.25 (100) | 7.53 ± 0.83 (100) | |
| Tenofovir | 30 | 1.34 ± 0.18 (83) | 7.23 ± 1.21 (96) |
| 300 | 1.62 ± 0.06 (101) | 8.79 ± 1.97 (116) | |
| ZDV | 30 | 2.26 ± 0.04 (141) | 10.39 ± 0.56 (138) |
| 300 | 3.32 ± 0.05 (207) | 21.94 ± 4.04 (291) | |
| 3TC | 30 | 1.92 ± 0.67 (119) | 7.29 ± 1.47 (97) |
| 300 | 1.94 ± 0.14 (121) | 8.13 ± 0.95 (108) | |
| ddC | 3 | 1.95 ± 0.26 (121) | 11.22 ± 3.15 (149) |
| 30 | 2.15 ± 0.42 (133) | 11.45 ± 2.09 (152) | |
a
The data are given as means ± standard deviations from a representative experiment performed in duplicate. HepG2 cells and SkMCs were incubated with the drugs for 3 and 6 days, respectively. Data in parentheses represent the percentages of the values for the untreated control.