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. 2025 Nov 22;25:1967. doi: 10.1186/s12903-025-07299-y

Table 1.

Characteristics of included RCTs

Author country (Year) Sample characteristics Index evaluated Mean(SD)
(intervention/control)
(data used in meta-analysis)
Size Lost to follow-up Age Supervisor Frequency of intervention Toothpaste fluoride concentration brushing technique Follow-up duration
(test/control)
1. Curnow et al. Scotland [15 279/255 40/33 5 years Local trained mothers school-days 1000 ppm* not mentioned 2 years dmfs*, DFS*  -
2. Rong et al.China [11] 361/370 103/114 3 years Teachers Twice a day, school-days 1100 ppm not mentioned 2 years dmfs

2.47(4.09)/

3.56(5.3)

3. Winter et al. Germany [16] 125/381 Not mentioned Primary school Trained dental assistants School-days 1400 ppm not mentioned 3 years dmf, DMF*  -
4. Al Jundi et al. Jordan [1]

6 years old: 218/212

11years old: 218/208

6 years old: 11/9

11years old: 14/14

6 and 11 years Research assistant School-days 500 ppm for 6 years old 1000 ppm for 11 years old horizontal scrub 4 years DMFT*, dmft*

6 Years-old: 0.02(3.2)/

0.26(3.25)

11 Years-old: 0.1(1.9)/

0.3(1.95)

5. Frazao Brazil [14] 344/283 53/37 5 years Dental assistant School-days 1100 ppm cross-brushing 18 month dmft  -
6. Jackson et al. Uk [10] 259/258 78/69 5–6 years Teachers School-day 1450 ppm/ toothbrushing technique appropriate for young children 2 years dmfs, DMFS*

2.58(12.24)/

2.93(11.97)

7. Helderman et al. Tanzania [13 400/150 91/28 9 to 14 years Teachers weekly No fluoride horizontal short stroke and marginal gingiva 3 years DMFT

0.5(0.26)/

0.4(0.26)

8. Schwarz et al. China [12] 168/121 16/22 3–4 years Teachers School-days 1000 ppm simple mini-scrub 3 years dmfs

3.6(5.55)/

6.3(7.56)

*dmft decayed, missing, and filled teeth – primary teeth, dmfs decayed, missing, and filled surfaces – primary teeth, DMF decayed, missing, and filled – permanent teeth, DMFT decayed, missing, and filled teeth – permanent teeth, DMFS decayed, missing, and filled surfaces – permanent teeth, DFS decayed and filled surfaces, PPM parts per million – fluoride concentration