TABLE 2.

Ability of pleurocidin, P-CN, P-M, and P-Der to bind to E. coli LPS and permeabilize E. coli outer membrane

Peptide	LPS bindinga		Time (min) required until maximal (100%) outer membrane permeabilization was achieved
	Imax (%)	IC50 (μg/ml)
Pleurocidin	78	32	5
P-CN	85	24	4
P-M	95	7	6
P-Der	67	16	5
Polymyxin B	100	5	2
Mg2+	60	140	NDb

^aI_max, maximal displacement of dansyl polymyxin B by the various peptides compared to the displacement caused by nondansylated polymyxin B, which is taken as 100%; IC₅₀, one-half of the peptide concentration required for maximal LPS binding.

^bND, not determined.