TABLE 1.

Concentrations of linezolid in plasma and CSF and other clinical data for five patients with CNS infections

Patient	Infection	Pathogena	Day of treatment	CSF protein (mg/dl)	CSF glucose (mg/dl)	CSF WBCb (no./μl)	Linezolidc
							CSF (μg/ml)	Plasma (μg/ml)	CSF/plasma ratio
1	Ventriculitis	MRSE	7	114	39	24	2.35	2.0	1.2
2	Meningitis	MRSE	6	132	44	52	2.3	1.83	1.25
			12	87	58	4	3.23	2.47	1.3
3	Meningitis	PSSP	6	217	33	122	1.46	0.54	2.7
			20	87	48	4	3.76	3.23	1.2
4	Meningitis	GP coccid	6	121	54	8	7.0 (6.9)	5.3 (12.4)	1.32 (0.55)
5	Meningitis	MRSA	8	63	43	200	3.9 (5.5)	1.71 (11.5)	2.3 (0.5)

^aMRSE, methicillin-resistant Staphylococcus epidermidis; MRSA, methicillin-resistant Staphylococcus aureus; PSSP, penicillin-susceptible Streptococcus pneumoniae.

^bWBC, leukocytes.

^cAt 0 h postdose. Values obtained at 1 h postdose are given in parentheses.

^dGram stain.