Table 4.

Different bacteria used for cancer as a therapeutic purpose. The tables represent different types of bacteria used in various types of cancers

Treatment Options	Types of bacteria	Results	References
Immunotherapeutic agents	Streptococcus pyogenes, Clostridium spp, Salmonella typhimurium Salmonella typhimurium	Rapid tumor regression Reduced frequency of cancer Tumor regression An antitumor effect	[162]
Vectors/spores to carry tumoricidal agent	Clostridium novyi-NT, C novyi‐NT and C. sporogenes, C novyi‐NT,	Elimination of tumors Hemorrhagic necrosis of tumors	[163]
Bacterial toxins/enzymes	Salmonella enterica Serovar Typhimurium, Streptococci and Serratia marcescens, Serratia marcescens (Coley’s Toxin) E coli BM2-1 strain)	Vaccine as an adjuvant against different types of cancer.	[164] [165]
Clostridium novyi-NT	Injection 3 × 108 spores of C novyi-NT	C novyi-NT plus external beam radiation led to tumor shrinkage in mice bearing HCT116 tumors	[166] [167]