Figure 2. Model of Haplotype-Based Selection Approach.

The image compares this approach, where the variants at the gene being studied are fully elaborated, to a model where the variants are not fully elaborated. At the top, multiple SNPs are genotyped to fully define the variants that exist in the gene. The resultant observed haplotype structure is shown in both bifurcation diagram and EHH plot formats (see Materials and Methods). At the bottom, only one SNP is genotyped, collapsing all other variants into a seemingly diverse super-haplotype and creating an impression of extension for the remaining haplotype.