Fig. 1.

Treatment effects in the sham-operated control rats. A, Sham-operated control rats received distilled water as control (SD), LCZ696 (SL), or valsartan (SV) for 4 wk (n = 6 in each group). B, Neither LCZ696 nor valsartan influenced portal pressure. C, LCZ696 and valsartan effectively reduced the mean arterial pressure. D, There were no significant differences in AST, ALT, or total bilirubin levels among the three groups. *p < 0.05, **p < 0.01. ALT = alanine aminotransferase; AST = aspartate aminotransferase; SMA = superior mesenteric artery; SRS = splenorenal shunt.