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Hepatic and extra-hepatic structural changes in the sham-operated rats with different treatment. A, Liver fibrosis was evaluated by Sirius red staining. Liver fibrosis severity was not affected by LCZ696 or valsartan. Scale bar = 1 mm. B, Extrahepatic angiogenesis was assessed by mesenteric immunofluorescent study. There were no significant differences in vascular area ratio or vascular length among three groups. SD = sham-distilled water; SL = sham-LCZ696; SV = sham-valsartan.
