Fig. 4.

Liver injury and systemic inflammation in the cirrhotic rats with different treatment. A, Plasma renin activity significantly increased and plasma aldosterone level significantly decreased. B, Plasma AST, ALT, and total bilirubin levels were not significantly different among the three groups. C, Plasma IL-1β and TNF-α levels were not significantly different among the three groups. ALT = alanine aminotransferase; AST = aspartate aminotransferase; BD = bile duct ligation-distilled water; BL = bile duct ligation-LCZ696; BV = bile duct ligation-valsartan; IL = interleukin; TNF = tumor necrosis factor.