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. 2005 Oct 27;33(19):6164–6171. doi: 10.1093/nar/gki913

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© The Author 2005. Published by Oxford University Press. All rights reserved

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(A) Co-orthology relationship between prpC of E.coli, mmgD and citZ of B.subtilis. mmgD is the SBH of prpC (unidirectional arrow), whereas citZ and prpC are BBHs (bidirectional arrow). prpC and mmgD show, in contrast to the BBH, conservation of neighboring genes, which are all involved in the methylcitrate cycle. citZ is part of the citric acid cycle and is therefore not functional equivalent to prpC, for details see text. (B) The neighboring genes prpB, prpC and prpD are indicated on the biochemical map of the methylcitrate cycle. The metabolic information is taken from Ecocyc (http://ecocyc.org/).