Table 1.

Overview of Data Sets

												No. of Subjects with BPb
						No. of Genetic Markersa		Diagnostic and Ascertainment Criteria				Narrow				Broad
Data Set	Reference	Population	Race	No. of Pedigrees	No. ofGenotyped Individuals	Genotyped	Mapped	DiagnosticCriterion(a)	Diagnosisof Proband	Schemec	Diagnosis ofAffected Relatived	Total	ARP	FS	IF	Total	ARP	FS	IF
Bonn	Cichon et al. 2001	Germany, Israel, Italy	White	75	387	389	386	DSM-IIIR	BPI	1SB	BPI, SAB, BPNOS, RUD	103	62	45	27	124	98	69	36
Columbia	Liu et al. 2003	Israel, U.S.	White	40	358	334	333	RDC	BPI, SAB	2FD+	BPI, SAB	115	97	38	31	200	309	92	35
Johns Hopkins 1	McInnis et al. 2003b	U.S.	Mixed	63	562	823	802	RDC	BPI	2FD+	BPI, BPII, SAB, RUD	125	73	65	32	216	243	169	55
Johns Hopkins 2	Fallin et al. 2004	U.S.	White	40	175	381	380	DSM-IV	BPI	1FD+	BPI, BPII	73	33	19	22	95	53	38	40
NIMH Wave 1	NIMH Genetics Initiative Bipolar Group 1997	U.S.	Mixed	95	525	357	351	DSM-IIIR, RDC	BPI	1FD	BPI, SAB	226	164	94	64	298	294	164	81
NIMH Wave 2	Dick et al. 2002; McInnis et al. 2003a; Willour et al. 2003; Zandi et al. 2003	U.S.	Mixed	55	348	465	458	DSM-IIIR, RDC	BPI	1FD	BPI, SAB	135	85	54	39	174	170	110	46
NIMH Wave 3	Dick et al. 2003; NIMH Human Genetics Initiative Web Site	U.S.	Mixed	220	982	372	372	DSM-IV	BPI	1SB	BPI, SAB	489	310	254	189	534	370	288	193
NIMH Wave 4	NIMH Human Genetics Initiative Web Site	U.S.	Mixed	274	1,053	384	384	DSM-IV	BPI	1SB	BPI, SAB	620	416	338	234	665	482	380	243
Portuguese	Pato et al. 2004	Portugal	White	16	102	346	342	DSM-IV	BPI	1FD	BPI, BPII, SAB	43	35	27	15	44	37	27	15
UCSD	Kelsoe et al. 2001	Canada, U.S.	White	20	163	331	324	DSM-IIIR	BPI, BPII	2FD+	BPI, BPII, SAB, RUD	27	11	7	7	41	21	15	12
Wellcome Trust	Bennett et al. 2002	Great Britain, Ireland	White	151	509	380	378	DSM-IV	BPI	1SB	BPI, BPII, BPNOS, RUD	288	159	150	109	313	195	186	122
Total				1,067	5,179	4,562	4,510					2,251	1,445	1,091	769	2,423	2,272	1,538	878

^aGenotyped=number of markers genotyped (autosomal only). Mapped=number of markers mapped to the common marker map (autosomal only).

^bARP=all possible ARPs; FS=all possible full-sibling pairs ; IF=families informative for nonparametric allele-sharing linkage analysis.

^cAscertainment scheme: 1SB=at least one affected sibling; 1FD=at least one affected first-degree relative; 1FD+=at least one affected first- or greater-degree relative; 2FD+=at least two affected first- or greater-degree relatives.

^dDiagnosis of the relative(s) of proband (satisfying ascertainment scheme). BPNOS=bipolar disorder–not otherwise specified.