Table 3.

Allelic Frequencies and Association Analysis of Dutch Patient-Control Sample of Early-Onset AD, at 7q36

	Allele Frequencya(%)		Pb
Marker and Allele (bp)	Patientsc(N=204)	Control Individuals (N=372)	Overall	Specific
D7S642:			.53
189	41.2	45.1		.40
191	13.7	14.2
193	1.0	2.2
195	23.5	21.8
197	18.6	13.2
199	2.0	3.0
201	.0	.3
D7S2439:			.12
191	.0	.3
193	.0	.3
195	28.4	28.0
197	5.9	4.8
199	24.5	19.4
201	29.4	27.7		.71
203	1.5	7.0
205	2.0	4.6
207	2.9	2.7
209	4.9	4.0
211	.5	.8
213	.0	.3
215	.0	.3
D7S798:			.03
76	.0	.8
78	6.4	5.6
80	4.9	1.9		0.04
82	10.8	14.8
84	23.0	24.7
86	.0	3.2
88	8.8	10.8
90	8.3	8.3
92	34.8	28.2
94	2.5	1.3
96	.5	.3
D7S2546:			.78
228	.5	.3
230	.5	.0
232	18.6	18.5		1.00
234	24.5	26.6
236	9.3	11.6
238	34.8	32.5
240	10.3	9.7
242	1.5	.5
244	.0	.3
D7S1823:			.48
201	.5	.0
205	11.8	14.5
209	15.2	14.5
213	3.9	4.6
217	12.3	12.9		.90
221	17.2	14.5
225	18.6	21.2
229	13.7	14.0
233	6.4	2.7
237	.5	1.1
D7S2465:			.25
158	.0	.3
160	.5	.3
161	3.4	1.1
164	2.0	1.6
168	1.0	.0
169	1.0	.5
171	3.9	5.1
173	22.1	22.8
174	.5	.5
175	23.5	26.1		.54
176	1.0	.5
177	4.9	6.5
178	17.6	12.6
179	4.9	2.2
180	5.4	8.6
181	1.5	1.9
182	1.0	3.2
183	2.0	3.0
184	3.9	3.0
186	.0	.3

^aN represents the number of chromosomes analyzed.

^bAssociation analyses of the linked allele versus all other alleles is shown as specific P values.

^cSix PSEN1 and two PSEN2 mutation carriers were excluded from the analysis (Cruts et al. 1998). APP, MAPT, and PRNP mutation carriers were not present in the Dutch patient population (van Duijn et al. 1991; Roks et al. 1999; Dermaut et al. 2003).