Table 3.
Cancer and Genotype or Comparisona | Skin Types I–IV | Skin Types I and II | Skin Types III and IV | Pooled OR (95% CI) b | |||
No. of Individuals |
|||||||
Controls |
Patients |
Controls |
Patients |
Controls |
Patients |
||
Squamous cell carcinoma: | |||||||
WT/WT | 137 | 26 | 50 | 15 | 87 | 11 | |
WT/Var | 174 | 74 | 79 | 44 | 95 | 30 | |
Var/Var | 74 |
53 |
51 |
41 |
23 |
12 |
|
OR (95% CI) |
|||||||
WT/Var vs. WT/WT | 2.24 (1.32–3.81) | 1.86 (.89–3.91) | 2.50 (1.12–5.67) | 2.13 (1.25–3.68) | |||
Var/Var vs. WT/WT | 3.77 (2.11–6.78) |
2.68 (1.25–5.80) |
4.13 (1.47–11.70) |
2.91 (1.62–5.58) | |||
No. of Individuals |
|||||||
Controls |
Patients |
Controls |
Patients |
Controls |
Patients |
||
Nodular basal cell carcinoma: | |||||||
WT/WT | 137 | 72 | 50 | 30 | 87 | 42 | |
WT/Var | 174 | 124 | 79 | 65 | 95 | 59 | |
Var/Var | 74 |
88 |
51 |
66 |
23 |
22 |
|
OR (95% CI) |
|||||||
WT/Var vs. WT/WT | 1.36 (.92–1.99) | 1.37 (.76–2.49) | 1.29 (.76–2.17) | 1.32 (.89–1.95) | |||
Var/Var vs. WT/WT | 2.26 (1.45–3.52) |
2.16 (1.16–4.03) |
1.98 (.94–4.19) |
1.98 (1.23–3.19) | |||
No. of Individuals |
|||||||
Controls |
Patients |
Controls |
Patients |
Controls |
Patients |
||
Superficial multifocal basal cell carcinoma: | |||||||
WT/WT | 137 | 27 | 50 | 10 | 87 | 17 | |
WT/Var | 174 | 65 | 79 | 31 | 95 | 34 | |
Var/Var | 74 |
50 |
51 |
42 |
23 |
8 |
|
OR (95% CI) |
|||||||
WT/Var vs. WT/WT | 1.90 (1.12–3.23) | 1.96 (.83–4.71) | 1.83 (.91–3.70) | 1.87 (1.09–3.21) | |||
Var/Var vs. WT/WT | 3.43 (1.92–6.15) | 4.12 (1.76–9.86) | 1.78 (.61–5.09) | 2.82 (1.45–5.22) |
WT = wild-type allele; Var = variant allele.
Adjusted for skin type, using Mantel-Haenszel weighted OR.