Table 3.

Risk of Nonmelanoma Skin Cancer Dependent on MC1R Gene Variants Stratified According to Skin Type

Cancer and Genotype or Comparisona	Skin Types I–IV		Skin Types I and II		Skin Types III and IV		Pooled OR (95% CI) b
	No. of Individuals
	Controls	Patients	Controls	Patients	Controls	Patients
Squamous cell carcinoma:
WT/WT	137	26	50	15	87	11
WT/Var	174	74	79	44	95	30
Var/Var	74	53	51	41	23	12
	OR (95% CI)
WT/Var vs. WT/WT	2.24 (1.32–3.81)		1.86 (.89–3.91)		2.50 (1.12–5.67)		2.13 (1.25–3.68)
Var/Var vs. WT/WT	3.77 (2.11–6.78)		2.68 (1.25–5.80)		4.13 (1.47–11.70)		2.91 (1.62–5.58)
	No. of Individuals
	Controls	Patients	Controls	Patients	Controls	Patients
Nodular basal cell carcinoma:
WT/WT	137	72	50	30	87	42
WT/Var	174	124	79	65	95	59
Var/Var	74	88	51	66	23	22
	OR (95% CI)
WT/Var vs. WT/WT	1.36 (.92–1.99)		1.37 (.76–2.49)		1.29 (.76–2.17)		1.32 (.89–1.95)
Var/Var vs. WT/WT	2.26 (1.45–3.52)		2.16 (1.16–4.03)		1.98 (.94–4.19)		1.98 (1.23–3.19)
	No. of Individuals
	Controls	Patients	Controls	Patients	Controls	Patients
Superficial multifocal basal cell carcinoma:
WT/WT	137	27	50	10	87	17
WT/Var	174	65	79	31	95	34
Var/Var	74	50	51	42	23	8
	OR (95% CI)
WT/Var vs. WT/WT	1.90 (1.12–3.23)		1.96 (.83–4.71)		1.83 (.91–3.70)		1.87 (1.09–3.21)
Var/Var vs. WT/WT	3.43 (1.92–6.15)		4.12 (1.76–9.86)		1.78 (.61–5.09)		2.82 (1.45–5.22)

^aWT = wild-type allele; Var = variant allele.

^bAdjusted for skin type, using Mantel-Haenszel weighted OR.