Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Geller syndrome pathophysiology. In normal gestation, progesterone acts as an antagonist of the mineralocorticoid receptor (MR). Contrary, in Geller syndrome, a gain-of-function mutation in the NR3C2 gene, specifically a serine-to-leucine substitution at position 810 (S810L), alters the receptor's ligand specificity, allowing progesterone to hyper-activate the MR. This leads to kaliuresis, hypokalemia, and arterial hypertension. Created with Biorender.com.
