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. 2025 Dec 9;29:100429. doi: 10.1016/j.metop.2025.100429

Table 3.

Geller syndrome cases described in the literature.

Study (Date) Article type/Origin Number of cases Detected mutation/gene Clinical featuresa Treatment during pregnancy
Geller D.S. et al. (2000) Original Article - Case series/USA (first description) 2b S810 L/NR3C2
  • -

    Early onset hypertension before pregnancy

  • -

    No other specific features described during pregnancy
  • -

    Not described
Mulkanoor V. et al. (2017) Conference Paper – Case series/USA 2 Genetic testing not performed
  • -

    Muscle weakness

  • -

    Bilateral lower extremity edema
  • -

    IV & PO K+ replacement

  • -

    Methyldopa and labetalol

  • -

    Amiloride
Garg A. K. et al. (2020) Original article - Case report/USA 1 Genetic testing not performed
  • -

    Bilateral lower extremity edema
  • -

    IV & PO K+ replacement
Pintavorn P. et al. (2021) Original article - Case report/USA 1 Genetic testing not performed
  • -

    Muscle weakness

  • -

    Rhabdomyolysis

  • -

    Nephrogenic DI
  • -

    IV K+ replacement

  • -

    Amiloride
Hindosh N. et al. (2022) Original article - Case report and literature review/USA 1 Genetic testing not performed
  • -

    Headaches and visual disturbances

  • -

    Bilateral lower extremity edema

  • -

    Preeclampsia
  • -

    IV K+ replacement

  • -

    Urgent C-section due to preeclampsia
Maturostrakul-Boonyanuth N. et al. (2022) Conference paper – Case report/USA 1 Pending results
  • -

    Early-onset hypertension before pregnancy

  • -

    Bilateral lower extremity edema
  • -

    K+ replacement
Bin Rhashbudin Shah et al. (2023) Conference paper – Case report/New Zealand 1 Genetic testing not performed
  • -

    Asymptomatic
  • -

    K+/Mg+2 replacement

  • -

    Amiloride
Suria M. et al. (2023) Conference paper – Case report/Malaysia 1 Genetic testing not performed
  • -

    Bilateral lower limp weakness

  • -

    Vomiting

  • -

    Persistent Tachycardia

  • -

    In-utero fetal death
  • -

    IV K+ replacement
Sarwal A. & Abraham J. (2023) Conference paper – Case report/USA 1 Genetic testing not performed
  • -

    Asymptomatic
  • -

    IV & PO K+ replacement
Gonuguntla S. et al. (2024) Conference paper – Case report/USA 1 Genetic testing not performed
  • -

    Preeclampsia
  • -

    Conservative management (no further description)

  • -

    C-section at 34 weeks
Valiveti D. et al. (2025) Original article - Case report/USA 1 Genetic testing not performed
  • -

    Paresthesia/lethargy

  • -

    Generalized weakness

  • -

    Pedal edema
  • -

    IV & PO K+/Mg+2 replacement
Cecchini A. et al. (2025) Conference paper - Case report/USA 1 Genetic testing not performed
  • -

    Preeclampsia
  • -

    IV K+ replacement

  • -

    IV Magnesium sulfate

  • -

    Labetalol

  • -

    Amiloride

  • -

    Urgent labor at 34 weeks
Chothia M. & Ndinya F. (2025) Original article – Case report/South Africa 1 Genetic testing not performed
  • -

    Visual disturbancies

  • -

    Lower abdominal pain

  • -

    Bilateral lower limb burning sensation

  • -

    Nephrotic syndrome (1m before)

  • -

    Preeclampsia
  • -

    IV & PO K+ replacement

  • -

    Doxazocin, labetalol and amlodipine

  • -

    IV Magnesium sulfate

  • -

    Urgent labor at 37 weeks
J.D. Tse et al. (2025) Original article – Case report/USA 1 Genetic testing did not reveal known mutations
  • -

    Nausea/Vomiting
  • -

    Nifedipine

  • -

    PO K+/Mg+2 replacement
Current paper (2025) Original article - Case report and literature review/Greece 1 Genetic testing did not reveal known mutations
  • -

    Muscle weakness

  • -

    Rhabdomyolysis

  • -

    Nephrogenic DI

  • -

    Bilateral lower extremity edema
  • -

    IV K+/Mg+2 replacement

  • -

    Methyldopa

  • -

    Amiloride
a

All the patients presented hypertension and hypokalemia during pregnancy.

b

The typical manifestations of Geller syndrome during pregnancy were described in two women S810L carriers that underwent 5 gestations. In total 11 family members carried the mutated NR3C2 gene.