TABLE 2.
Protection of piglets against erysipelas after intranasal immunization with E. rhusiopathiae YS-19
| Treatment group (no. of vaccinations)a and pig no. | Presence of clinical sign after challenge
|
||||
|---|---|---|---|---|---|
| Tempb | Erythemac | Depression | Death | Isolation of E. rhusiopathiae from organs | |
| A (0) | |||||
| 251 | +++ | +++ | Yes | Died (4)d | Yes |
| 252 | +++ | +++ | Yes | Died (4) | Yes |
| 253 | +++ | +++ | Yes | Died (4) | Yes |
| B(1) | |||||
| 254 | +++ | +++ | Yes | Euthanatized(5) | Yes |
| 255 | ++ | +++ | Yes | Died (3) | Yes |
| 256 | +++ | +++ | Yes | Died (5) | Yes |
| C(2) | |||||
| 257 | − | ± | No | No | |
| 258 | + | + | No | No | |
| 259 | − | ± | No | No | |
a
Seven-day-old SPF piglets were immunized intranasally with 109 CFU of YS-19 on day 0 and boosted on day 14 (group C only). The piglets were challenged intradermally with 107 CFU of E. rhusiopathiae Fujisawa-SmR on day 50.
b
Maximum measured rectal temperature. −, <40°C; +, 40 to 41°C; ++, 41 to 42°C; +++, >42°C.
c
±, a skin lesion at the inoculation site; +, a few localized skin lesions in addition to the lesion at the inoculation site; +++, systemic erythema.
d
The value in parentheses indicates the day when the piglet died or was sacrificed after the challenge.