Figure 6.

Mapping of Site-Directed Mutagenesis Results onto the ToxA Structure.

The molecular surface of ToxA is colored to highlight the sites of fully active mutants (green), partially active or inactive mutants that are expected to disrupt the structure (yellow), and partially active or inactive mutants that are expected to be nondisruptive (purple). All residues except Thr132, Gly141, and Val143 are visible in these views. The surface on the left is in the same orientation as Figure 3A, while the surface on the right is rotated 180° around the vertical to show the other side of the protein. The figure was generated using Pymol (www.pymol.org).