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Hypersensitivity of IRF-4-/- mice to LPS in vivo.(A) IRF-4-/- mice and their littermates were injected i.p. with LPS. (B) IRF-4-/-, C57BL/6 (IRF-4+/+), and IRF-4-/- TNF-α receptor-/- DKO mice were injected i.p. with LPS. (C) Serum from IRF-4+/+ and IRF-4-/- mice was collected 2 h after LPS challenge. TNF-α and IL-12 p70 levels were measured by ELISA. Each circle represents an individual mouse, and the bars represent the average of each group.
