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. 2005 Oct 21;102(44):16001–16006. doi: 10.1073/pnas.0504226102

Fig. 6.

Fig. 6.

LPS tolerance can be induced in IRF-4-/- macrophages. (A) Peritoneal macrophages were treated with LPS (1 μg/ml). The expression levels of SOCS-3, IRAK-M, and G3PDH were analyzed by Northern blotting. The relative levels of SOCS-1 mRNA were determined by real-time RT-PCR (open bars, IRF-4+/+; gray bars, IRF-4-/-). (B) Peritoneal macrophages were treated with LPS (100 ng/ml) or left untreated. After 24 h, cells were washed and restimulated with LPS (100 ng/ml) for an additional 24 h. N.D., not detected.