Table 1. Effect of genotype on susceptibility to organ dysfunction in humans eating low-choline diets.
| Polymorphism | Genotype (n) | % subjects with signs of choline deficiency | P | Odds ratio and 95% CI |
|---|---|---|---|---|
| MTHFR 677 | CC (28) | 61 | 0.63 | CC vs. CT/TT |
| CT (22) | 73 | Odds ratio, 1.76 | ||
| TT (4) | 75 | 95% CI, 0.56–5.6 | ||
| MTHFR 1298 | AA (28) | 64 | 0.90 | AA vs AC/CC |
| AC (22) | 68 | Odds ratio, 1.25 | ||
| CC (4) | 75 | 95% CI, 0.40–3.9 | ||
| MTHFD1 1958 | GG (20) | 40 | 0.007 | GG vs GA/AA |
| GA (28) | 82 | Odds ratio, 7.0 | ||
| AA (6) | 83 | 95% CI, 2.0–25 | ||
| RFC1 80 | AA (19) | 56 | 0.59 | AA vs AG/GG |
| AG (20) | 70 | Odds ratio, 1.82 | ||
| GG (15) | 73 | 95% CI, 0.56–5.9 |
Significance was calculated with 2×3 Fisher's exact test. Application of Bonferroni's correction for multiple testing lowers the threshold for statistical significance to 0.0125.