Fig. 4.

Effects of dopaminergic antagonists on the behavioral abnormalities of EP1-deficient mice. Wild-type (open bars) or Ptger1^-/- (filled bars) male mice were treated with SCH23390 (SCH) (12.5 μg/kg i.p.), haloperidol (hal) (0.3 mg/kg per os), or raclopride (rac) (0.3 or 0.6 mg/kg i.p.) and were subsequently examined for electric-shock-induced fighting (A), the acoustic startle reflex to a 110-dB stimulus (B), and spontaneous locomotor activity (C). All of the tests were run simultaneously with corresponding control groups with proper vehicle (veh) over multiple days. The numbers of mice for each group are shown below each column. *, P < 0.05; **, P < 0.01 compared with vehicle-treated mice of the same genotype.