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Fidelity of replication of thymidine analogs of various sizes by normal (Upper) and SOS-induced bypass (Lower) polymerases in E. coli. The distribution of G (green), A (red), T (blue), and C (yellow) at the analog site from the phage progeny is shown. Because the analogs function like T in vivo, T replaces them in the progeny. Base compositions were obtained in triplicate as described in Supporting Materials and Methods, with one standard deviation shown.
