Table 1. In vivo antiinflammatory effects of CpdA in a zymosan-induced inflamed paw mouse model.
Group | Pretreatment | Difference zymosan–PBS | P value compared with PBS group | P value compared with ethanol group | P value DEX compared with CpdA group |
---|---|---|---|---|---|
1 | PBS | 2.02 ± 0.30 | 0.381 (NS) | ||
2 | Ethanol | 1.89 ± 0.23 | 0.381 (NS) | ||
3 | DEX | 1.20 ± 0.39 | 0.0009 (***) | 0.0017 (**) | |
4 | CpdA | 1.07 ± 0.42 | 0.0004 (***) | 0.0007 (***) | 0.5596 (NS) |
Mice were injected s.c. with zymosan in the footpad, and swelling was determined at 24 h after the injection. Pretreatment with CpdA, DEX, or solvent was for 30 min. Means ± SD were compared with a Student t test. ** and ***, 0.001 ≤ P < 0.01 and P < 0.001, respectively. NS, not significant.