TABLE 1.
Effect of IL-2 supplementation on IFN-γ production in response to M. avium in vitro
| IL-2 added (IU/ml) | IFN-γ production (IFN-γ units/105 CD4+ T cells)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Mice infected for 8 weeks
|
Mice infected for 39 weeks
|
Young normal mice
|
Old normal mice
|
|||||
| With M. avium | Without M. avium | With M. avium | Without M. avium | With M. avium | Without M. avium | With M. avium | Without M. aviumb | |
| 0 | 160 ± 108 | <1 | 11 ± 14c | <1 | <1 | <1 | <1 | <1 |
| 1 | 632 ± 218 | <1 | 36 ± 47d | 10 ± 9 | 192 ± 169 | <1 | 220 ± 105 | <1 |
| 100 | 1,406 ± 694 | <1 | 73 ± 109c | 45 ± 21 | 468 ± 317 | <1 | 1,397 ± 802 | <1 |
a
The values are means ± standard deviations based on the data for individual cultures from groups of five mice.
b
The P value was <0.01 for all comparisons with old uninfected mice.
c
Significantly different (P < 0.02) from the value obtained for mice infected for 8 weeks.
d
Significantly different (P < 0.001) from the value obtained for mice infected for 8 weeks.