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Topology of TASK2 and location of mutated residues. Diagrammatic representation of TASK2 structure showing four transmembrane domains (M1–M4) and two pore-domains (P1 and P2). OUT and IN refer to extracellular and intracellular compartments, respectively, and the cell membrane is delimited by the parallel, horizontal lines. Solid circles identify the charged residues in the extracellular domains, all of which were mutated in this study.
