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Effect of combined mutations on TASK2 pH sensitivity. pH dose–response curves of WT (▪, n = 14), 2M (E28Q and K47N; ♦, n = 8), 3M (K32N, K35N, and K42N triple mutant; ▴, n = 8), 4M (E28Q, K32N, K35N, and K42N quadruple mutant; •, n = 7), and 5M (E28Q, K32N, K35N, K42N, and K47N quintuple mutant; ▾, n = 8). Solid curves are best fits to the Langmuir equation. GNorm = conductance normalized to that at pH 8.8.
