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. 2002 Jan;70(1):257–267. doi: 10.1128/IAI.70.1.257-267.2002

FIG. 3.

FIG. 3.

P. gingivalis fimbrillin peptide-specific antisera inhibits ICAM-1, VCAM-1, and E- and P-selectin expression in P. gingivalis-infected HUVEC. P. gingivalis strain 381 cultures were preincubated with P. gingivalis fimbrillin-specific antisera for 2 h under anaerobic conditions prior to the addition to HUVEC. Following a 48-h incubation, HUVEC were harvested and processed for FACS analysis for detection of ICAM-1 (A), VCAM-1 (B), P-selectin (C), and E-selectin (D). In uninfected HUVEC (diagonal bars), HUVEC infected with P. gingivalis (gray bars), P. gingivalis incubated with normal rabbit serum (black bars), and HUVEC infected with P. gingivalis preincubated with fimbrillin-specific antisera (open bars), values are the means ± standard errors of the means for three independent experiments. Statistical significance was assigned when the P value was <0.05 (*) or <0.001 (**) compared to uninfected HUVEC.