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. 2005 Oct 20;102(44):15977–15982. doi: 10.1073/pnas.0508310102

Fig. 1.

Fig. 1.

Phenotypes of Er mutant mice. (A)An Er/+ heterozygous mouse (top) shows repeated hair loss and regrowth. (B) An Er/Er fetus at E18.5 (right) shows abnormal morphology, including shining skin with short limbs and tail. (C and D) Hematoxylin and eosin-stained sagittal sections of the dorsal skin from E18.5 embryos. Immunostaining of the sagittal sections of the dorsal skins from WT (E, G, I, K, M, and O) and Er/Er (F, H, J, L, N, and P) E18.5 embryos using anti-K14 (E and F), anti-K5 (G and H), anti-K6 (I and J), anti-K10 (K and L), antiloricrin (M and N), and anti-filaggrin (O and P) antibodies. Positive cells are stained red. Nuclei stained with DAPI are blue. (Q and R) Primary keratinocyte culture from WT (Q) and Er/Er (R) E18.5 embryos.