Figure 4:

TP53-wildtype high-grade carcinomas derived from low-grade serous neoplasms. (A, B) Case 3. (A) Photomicrographs of primary ovarian LGSC, pelvic lymph node metastasis with endosalpingiosis, and recurrent high-grade Mullerian carcinoma. (B) Phylogenetic tree based on mutations and LOH events. (C, D) Case 7. Photomicrographs of primary ovarian LGSC and recurrent undifferentiated carcinoma with sarcomatoid features. (D) Phylogenetic tree based on mutations and LOH events. SNV - single nucleotide variants; DEL – deletion; INS – insertion; LOH – loss-of-heterozygosity.