Figure 5:

Recurrent indeterminate-grade serous carcinoma (IGSC) with moderate (Grade 2) nuclear atypia and lacking TP53 mutations. (A-B) Case 2 (A) Photomicrographs of the primary ovarian serous borderline tumor and recurrent IGSC. (B) Phylogenetic tree based on mutations and LOH events. (C-E) Case 6. (C) Photomicrographs of primary ovarian micropapillary serous borderline tumor (miSBT) low-grade serous carcinoma (LGSC), and subsequent recurrent tumors, IGSC and LGSC, respectively. (D) Genome-wide copy number plots for each sample. (E) Phylogenetic tree based on mutations and LOH events. SNV - single nucleotide variants; DEL – deletion; INS – insertion; LOH – loss-of-heterozygosity.