Fig. 1.

Flow diagram of patient categorizations. Thirty-nine patients with grade III/IV glioma were enrolled. SD, stable disease; PD, progressive disease; PR, partial response; RR, radiographic response by MRI. ^*, Three patients did not undergo MRI scans, including one patient who entered hospice without receiving adjuvant therapy, one patient who declined further participation, and one patient who had claustrophobia and could not tolerate the MRI procedure. #, Two patients stratified as PD by fDM did not have radiographic follow-up at 10 weeks, including one who died secondary to neutropenia and sepsis and one who did not receive the first posttreatment scan until week 22. ¥, Three patients stratified as SD/PR by fDM did not have radiographic follow-up at 10 weeks, including one patient who died at 6 weeks before radiographic evaluation, one who was lost to follow-up, and one who had salvage surgery shortly after completing radiotherapy. ¶, Two patients had large cystic lesions requiring the insertion of a catheter and frequent aspiration of fluid, which made their scans nondiagnostic both by fDM and by CDP.