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. 2002 Feb;70(2):620–630. doi: 10.1128/iai.70.2.620-630.2002

FIG. 2.

FIG. 2.

S. aureus adherence to HAEC in the humanized tracheal xenograft model. (A) Schematic drawing of the humanized xenograft model in the nude mouse. The rat tracheas (RT), two per mouse, are seeded with HAEC and subcutaneously implanted in the flanks of a nude mouse. The tracheas are connected to polyethylene tubing and can be externally filled with culture medium or bacterial suspension. (B to E) Adherence of Cowan III during the regeneration and maturation process of the human airway epithelium after 3 days (B), 5 days (C), 15 days (D), and 30 days (E) of xenograft implantation in the nude mouse. (F to H) Adherence of strain 8325-4 (F) and FnBPs-deficient (G) and FnBPA-overexpressing (H) strains of S. aureus to HAEC after 3 days of xenograft implantation in the nude mouse. RT, rat trachea; M, mucus.