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. 2005 Oct 25;391(Pt 3):449–464. doi: 10.1042/BJ20050872

Figure 1. Domain structure of SHRs.

Figure 1

The overall organization of the NTD, DBD and LBD is shown in schematic representation at the top of the Figure. The variable lengths of the different SHR-NTDs are illustrated below, together with representative structures for the DBD and hormone-bound LBD (note that the hinge region connecting the DBD and LBD has not been determined structurally). The position of regions important for transactivation (AF1 and 3) that have been mapped to sequences in the NTD are shown as yellow shaded bars.