Table 1. Selective protein–protein interactions involving the SHR-NTD.

Abbreviations: aa, amino acids. FL, interaction with full-length receptor, although binding site/region not delineated; –, no interaction observed; ?, studied in reporter gene assays, but receptor binding site not delineated; ns, not studied.

Protein	AR	GR	ERα/β	MR	PR	References
GTFs
TFIID/TBP	aa 142–485	aa 77–262;	aa 1–185 (α)	ns	ns	[42,45,110–112,139]
		aa 187–244
TFIIF	aa 142–485	ns	ns	ns	ns	[23,111,137]
TFIIH	aa 38–561	ns	ns	ns	ns	[114]
pTEFb	aa 38–643	ns	ns	ns	ns	[115]
ELL	?	FL	ns	aa 163–437;	ns	[116]
				aa 445–602
Co-activators
ARA24	aa 11–208	ns	ns	ns	ns	[158]
ARA160	aa 38–643	?	ns	ns	?	[159]
ART27	aa 153–336†;	aa 107–237†	?	ns	ns	[160]
	aa 336–500†
CBP/p300	aa 1–503;	aa 187–244	aa 1–184 (α);	aa 1–169	?	[45,51,161–165]
	aa 297–640†;		aa 56–72 (α);
	aa 142–485‡		aa 62–72 (β)
p68	?	ns	aa 1–180 (α)	?	ns	[85]
RHA	ns	ns	ns	aa 1–169	ns	[164]
SAGA complex* (ada2)	ns	aa 77–262;	ns	ns	ns	[45,166]
		aa 187–244
SRC-1	aa 1–555;	–	?	?	aa 1–535;	[23, 32,121–125]
	aa 142–485;				aa 163–534
	aa 360–494
SRC-2	aa 1–555	?	aa 38–116 (α)	?	?	[51,32,121,123]
SRC-3	aa 1–660	ns	aa 1–184 (α)	ns	?	[121,126]
SWI/SNF complex* (?)	ns	aa 77–262;	–	ns	ns	[167]
TRAP/DRIP complex* (DRIP150)	–	aa 107–237†	ns	ns	ns	[168]
Co-repressors
AES	aa 1–599	ns	–	ns	ns	[169]
DAXX	aa 1–560	aa 1–450	ns	aa 170–433	ns	[129,170]
FLASH	?	aa 1–450	ns	aa 170–433	?	[129–131]
HEY-1	aa 1–556	–	–	ns	–	[128]
NcoR	aa 1–500;	aa 1–551;	?	ns	aa 468–508	[62,171]
	aa 171–505	aa 154–236;
		aa 206–236
SMRT	aa 1–682;	aa 154–236;	?	ns	aa 468–508	[62,172]
	aa 171–328	aa 206–236
Co-regulators
BAG-1	aa 360–554	?	?	ns	ns	[132,173]
CHIP	aa 220–270;	?	ns	ns	ns	[26]
PIAS1/xα/Miz1	aa 544–634/DBD	FL	FL (α/β)	aa 1–602	FL	[87,91,174]
Prp6p (ANT-1)	aa 1–153	aa 14–438	–	ns	ns	[175]
TSG101	aa 18–500†	aa 107–237†	ns	ns	ns	[168]

*Multi-subunit complexes. SHR-NTD binding partner indicated in brackets, where known.

†Amino acids for the rat AR and GR.

‡D. N. Lavery and I. J. McEwan, unpublished work.