Table 2. Biliary cholesterol saturation index in L-FABP wild-type (+/+) and L-FABP gene-ablated (−/−) mice.

Biliary total lipid (bile acid, cholesterol and phospholipid) concentrations were calculated as described in the Experimental section and are expressed as g/dl. Phospholipid/(bile acid+phospholipid) data are expressed as molar ratios. Cholesterol is expressed in mol% and was determined from the relationship mol% cholesterol=[cholesterol/(cholesterol+bile acid+phospholipid)]×100. The cholesterol saturation index was determined from the critical tables for calculating cholesterol saturation in bile as described in the Experimental section. The data represent the means±S.E.M. **, P<0.01 for L-FABP (−/−) versus L-FABP (+/+); ***, P<0.001 for L-FABP (−/−) versus L-FABP (+/+); ###, P<0.001 for cholesterol diet versus control diet; ‡‡‡, P<0.001 for cholesterol (mol%) versus cholesterol saturation index.

		L-FABP (+/+)		L-FABP (−/−)
Parameter	Diet…	Control	Cholesterol	Control	Cholesterol
Total lipid (g/dl)		7.5±0.7	7.2±0.1	11±1**	5.1±0.4***,###
Phospholipid/(bile acid+phospholipid) (mol/mol)		0.14±0.02	0.18±0.02	0.13±0.01	0.43±0.05***,###
Cholesterol (mol%)		5.6±0.7	6.7±0.3	4.7±0.7	19±1***,###,‡‡‡
Cholesterol saturation index (mol%)		4.8±0.4	5.7±0.4	4.8±0.1	7.2±0.2**,###