Table 4. Effect of altered biliary phenotype on liver lipids in L-FABP gene-ablated mice.

Lipid was extracted from liver homogenates of male mice as described in the Experimental section. Lipids were quantified by comparison with a standard curve generated for each lipid class. Lipid concentrations are expressed in units of nmol of lipid per mg of liver homogenate protein. The data represent the means±S.E.M. For L-FABP (−/−) versus L-FABP (+/+): *, P<0.05; **, P<0.01. ***, P<0.001. For cholesterol diet versus control diet: ##, P<0.01; ###, P<0.001.

		L-FABP (+/+)		L-FABP (−/−)
Lipid class	Diet…	Control	Cholesterol	Control	Cholesterol
Cholesterol		24±4	24±3	21±2	33±2*,##
Cholesteryl ester		10±1	27±4##	10±3	44±6**,###
Non-esterified fatty acid		20±3	21±3	42±7*	57±8***
Triacylglycerol		90±10	90±10	28±6**	90±10###
Phospholipid		100±10	280±40###	140±20	260±20##
Total cholesterol		34±5	51±6##	31±5	78±8**,###
Total lipid		250±20	440±60###	240±20	480±30###