Figure 1. Schematic amino acid structure of FoxO6.

FoxO6 contains two conserved PKB motifs and one putative PKB motif. FoxO6 contains an N-terminal PKB site (Thr²⁶), which is preferentially phosphorylated by SGK (serum and glucocorticoid regulated kinase), and a PKB site in the forkhead domain (Ser¹⁸⁴), which is phosphorylated by PKB. Phosphorylation of Ser¹⁸⁴ possibly obscures the NLS, which is located around the PKB motif. In the FoxO6 C-terminal region, a putative optimal PKB motif is present (Thr³³⁸) next to an NES. In the C-terminal region, FoxO6 contains an LXXLL motif implicated in nuclear receptor interactions.