Table 1.
Systemic, renal and cerebral variables at baseline and at 23-h after induction of sepsis
| Variables | Pooled (n = 30) | 3.0 g/kg Na ascorbate (n = 8) |
|
|---|---|---|---|
| Baseline | 23-h of sepsis (prior to treatment) |
31-h of sepsis (end of treatment) |
|
| Systemic | |||
| Mean arterial pressure (mmHg) | 87.0 ± 8.1 | 68.8 ± 2.3 **** | 74.0 ± 2.6* |
| Heart rate (beats/min) | 77.4 ± 2.2 | 144.1 ± 4.0 **** | 133.9 ± 9.3** |
| Cardiac output (L/min) | 4.3 ± 0.6 | 6.2 ± 0.2 **** | 7.3 ± 0.6** |
| Total peripheral resistance (ml/min/mmHg) | 49.7 ± 1.2 | 93.3 ± 4.5**** | 100.6 ± 10.5** |
| Core body temperature (℃) | 39.7 ± 0.1 | 41.5 ± 0.1 **** | 39.7 ± 0.2 |
| Arterial blood lactate (mmol/L) | 0.63 ± 0.04 | 1.50 ± 0.1 **** | 1.5 ± 0.3 |
| Arterial blood pH | 7.52 ± 0.01 | 7.54 ± 0.005**** | 7.49 ± 0.01 |
| Renal | |||
| Renal blood flow (mL/min) | 248.9 ± 9.6 | 330.0 ± 16.9 **** | 387.3 ± 34.3** |
| Medullary tissue pO2 (mmHg) | 43.6 ± 1.6 | 24.3 ± 2.0 **** | 43.4 ± 4.5 |
| Medullary tissue perfusion (BPU) | 1143 ± 140 | 650 ± 70 *** | 892.3 ± 203.5 |
| Cortical tissue pO2 (mmHg) | 38.8 ± 2.3 | 43.2 ± 2.9 | 40.5 ± 6.4 |
| Cortical tissue perfusion (BPU) | 2140 ± 343 | 1931 ± 314 | 2547 ± 213 |
| Urine output (mL/kg/h) | 1.47 ± 0.13 | 0.52 ± 0.10 **** | 6.92 ± 0.84*** |
| Plasma creatinine (µmol/L) | 67.1 ± 2.0 | 141.8 ± 8.9 **** | 18.8 ± 3.8**** |
| Creatinine clearance (mmol/kg/min) | 2.15 ± 0.13 | 0.86 ± 0.10 **** | 36.6 ± 13.0* |
| Cerebral | |||
| Cerebral tissue pO2 (mmHg) | 35.7 ± 1.5 | 17.3 ± 2.1 **** | 31.2 ± 1.6 |
| Cerebral tissue perfusion (BPU) | 978 ± 164 | 1045 ± 173 | 652.7 ± 150.4 |
| Cerebral tissue temperature (℃) | 39.5 ± 0.1 | 40.8 ± 0.1 **** | 39.5 ± 0.3 |
BPU: blood perfusion units. Data are expressed as mean ± standard error of mean. P-values were derived from a Student’s paired t-test comparing either 23.5-h or 31-h of sepsis to their respective baseline levels. *P ≤ 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001