Table 2.
Summary of the effectiveness of 7-h of sodium ascorbate treatment to normalise sepsisinduced changes in renal, cerebral and systemic variables to their pre-morbid levels
| Variables | Dose of ascorbate | |||
|---|---|---|---|---|
| 3.0 g/kg | 2.0 g/kg | 1.0 g/kg | Vehicle | |
| Renal | ||||
| Plasma creatinine (µmol/L) | + + + | + + | + | - |
| Creatinine clearance (mmol/min) | + + + | + + | - | - |
| Medullary tissue pO2 (mmHg) | + + + | + + | + | - |
| Medullary tissue perfusion (BPU) | - | - | - | - |
| Urine flow (mL/kg/h) | + + + | + + | + | - |
| Cerebral | ||||
| Cerebral tissue pO2 (mmHg) | + | - | - | - |
| Cerebral tissue temperature (℃) | + | + | + | - |
| Systemic | ||||
| Noradrenaline required | + | - | - | - |
| Heart rate (beats/min) | - | - | - | - |
| Cardiac output (L/min) | - | - | - | - |
| Core body temperature (℃) | + | + | + | - |
| Arterial blood lactate (mmol/L) | + | + | + | - |
| Arterial blood pH | - | - | - | - |
‘ + ’ indicates normalisation of variable at 31-h to its pre-morbid levels and the number of ‘ + ’ indicates magnitude of improvements. ‘-’ indicates no significant improvement detected