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. 2005 Nov 4;102(46):16880–16885. doi: 10.1073/pnas.0508202102

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Copyright © 2005, The National Academy of Sciences

Freely available online through the PNAS open access option.

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Fig. 5. — GHRH triggers sustained changes in GH cell connectivity in the median zone. (A-D) GHRH (10 nM) was applied during a 15-min time period (horizontal bar). (A) GHRH triggered a prolonged change in calcium spiking activity. (B)Cross-correlation (Pearson R) between cell pairs. Arrows indicate cell pairs with high R values after GHRH application (P < 0.001). (C) Numbers of cell pairs with significant cell connectivity (P < 0.001). Paradoxically, GHRH also caused a delayed decrease in the numbers of connected cell pairs (P < 0.05). (D-F) Changes in both calcium spike firing and cell connectivity (Pearson R) in a pair of neighboring GH cells before (D), during (E), and after (F) GHRH application. The cell pair corresponded to a trace marked by an arrow in B.