Table 3. Adjusted and unadjusted estimates of association of antenatal steroid exposure with SITAR derived height metrics.
| Dependent variable: | Boys | Girls | ||||
|---|---|---|---|---|---|---|
| Independent variable: exposure to antenatal steroids: yes regression estimate (95% CI) | Model R² (adjusted | unadjusted) | Independent variable: exposure to antenatal steroids: yes regression estimate (95% CI) | Model R² (adjusted | unadjusted) | |||
| Metrics calculated from modelling: | Adjusted for covariates* | Unadjusted | Adjusted for covariate exposure to antenatal steroids: yes regression estimates* | Unadjusted | ||
| Height at 18 years (cm) | −3.8 (−8.9 to 1.3) | −2.0 (−5.5 to 1.6) | 0.36 | 0.01 | 2.8 (0.3 to 5.3) | 1.1 (−1.5 to 3.7) | 0.56 | 0.01 |
| Peak height velocity (cm/year) | −0.5 (−1.2 to 0.2) | 0.0 (−0.5 to 0.4) | 0.17 | 0.01 | 0.4 (−0.2 to 0.9) | 0.5 (0.1 to 0.9) | 0.24 | 0.09 |
| Age at peak height velocity (years) | 0.4 (−0.3 to 1.1) | −0.1 (−0.5 to 0.3) | 0.07 | 0.01 | −0.1 (−0.8 to 0.5) | −0.4 (−0.9 to 0.1) | 0.08 | 0.04 |
| SITAR patient-level random effects: | ||||||
| Size (cm) | −1.0 (−4.8 to 2.7) | −2.0 (−4.7 to 0.7) | 0.44 | 0.03 | 2.9 (0.4 to 5.4) | 1.2 (−1.4 to 3.8) | 0.55 | 0.01 |
| Timing (%) | 1.7 (−3.4 to 6.7) | −1.3 (−4.8 to 2.2) | 0.38 | 0.01 | 3.0 (−2.0 to 8.0) | 0.9 (−3.0 to 4.9) | 0.24 | 0.01 |
| Intensity (%) | −1.8 (−5.5 to 1.9) | −0.7 (−3.3 to 2.0) | 0.40 | 0.01 | 3.5 (1.0 to 6.0) | 3.4 (0.9 to 5.8) | 0.55 | 0.10 |
Statistically significant estimates highlighted in bold. The raw model coefficient for timing and intensity is multiplied by 100 to represent percentage difference between patients exposed and not exposed to steroid. Positive timing represents a later pubertal growth spurt, positive intensity representing a compressed, or faster, pubertal growth spurt.
SITAR, SuperImposition by Translation and Rotation.