TABLE 1.

Production of IL-12 p40 by BALB/c LC after treatment with IL-4 and/or LPS^a

Cells	Infection with L. major	Amt of IL-12 p40 (ng/ml)b in cells cultured in:
		Medium	Medium + LPS	Medium + IL-4	Medium + LPS and IL-4
LC	−	0.8	1.2	1.3	0.8
	+	0.7	0.7	0.6	0.4
LC pretreated with anti-IL-4 MAb	−	0.3	1.3	0.7	0.5
	+	0.4	1.2	0.5	0.2

^aLC or LC pretreated with anti-IL-4 MAb, uninfected or infected with L. major, were cultured in the absence or presence of LPS (100 ng/ml) and/or IL-4 (5 ng/ml). IL-12 p40 concentrations in culture supernatants were determined after 6 days by ELISA. Shown are the results of one representative experiment of four experiments (LC) or three experiments (LC plus anti-IL-4 MAb) with similar results.

^bStandard deviation amounts were below 0.15 ng/ml.